quadruplex+DNA

This is the page for the Quadruplex DNA - Polymer Binding Project.

The goal of this project is to first prepare molecules that may bind to quadruplex DNA based on similarity to known quadruplex binding drugs. These will then be evaluated for binding to quadruplex DNA via melting curves, gel electrophoresis, and light scattering. Finally, we may make polymers that incorporate the most effective of these binding moieties and evaluate the binding of these polymers to quadruplex DNA.

Here is an overview of the synthetic chemistry:

We have done a few of the procedures before:

Here are the new procedures as of February 8 2009:

Jamie Gates will make the following compounds: reaction of pyridine dicarbonyl chloride with diaminopyridine and diaminoanthraquinone reaction of melamine with pyridine dicarbonyl chloride followed by the 3 amines, and succinyl chloride followed by the two heterocyclic amines.

Sarah Osmun will make the following compounds: reaction of pyridine dicarbonyl chloride with the three triazine and pyrimidine derivatives reaction of melamine with isophthaloyl chloride followed by the 3 amines.